CTO MESSAGE

ABOUT COGNOHEAL

The clinical manifestations resulting from AD include memory and cognitive impairment, anxiety, confusion, language difficulties, and mood swings. Current treatments including acetylcholine esterase inhibitors or NMDA receptors antagonists are somehow symptomatic, showing side-effects and may not heal the disease. Despite extensive considerations, an efficient therapeutic has remained elusive thus far.

CTO MESSAGE

ABOUT COGNOHEAL

The clinical manifestations resulting from AD include memory and cognitive impairment, anxiety, confusion, language difficulties, and mood swings. Current treatments including acetylcholine esterase inhibitors or NMDA receptors antagonists are somehow symptomatic, showing side-effects and may not heal the disease. Despite extensive considerations, an efficient therapeutic has remained elusive thus far.

ALZHEIMER’S DISEASE

DIAGNOSIS KIT


We have previously shown the pathogenic pT231-tau, which is an early driver of tauopathy and neurodegeneration, is having a prion nature and spreads in brain areas as well as CSF and even into the blood. As mentioned earlier, we have now generated a fully human monoclonal antibody (scFv domain) against the pathogenic conformer and have shown that antibody specifically recognizes the pathogenic p-tau species.

ALZHEIMER’S DISEASE

DIAGNOSIS KIT


We have previously shown the pathogenic pT231-tau, which is an early driver of tauopathy and neurodegeneration, is having a prion nature and spreads in brain areas as well as CSF and even into the blood. As mentioned earlier, we have now generated a fully human monoclonal antibody (scFv domain) against the pathogenic conformer and have shown that antibody specifically recognizes the pathogenic p-tau species.

SPECT TAU IMAGING


WThere is a gradual increase in the pT231-tau epitope confirmed by immunostaining of human AD postmortem brains. Moreover, we performed immunoblotting analysis on human AD and healthy brain extracts using our antibody and compared the results with anti cis pT231-tau mouse monoclonal antibody.
Learn More

SPECT TAU IMAGING


WThere is a gradual increase in the pT231-tau epitope confirmed by immunostaining of human AD postmortem brains. Moreover, we performed immunoblotting analysis on human AD and healthy brain extracts using our antibody and compared the results with anti cis pT231-tau mouse monoclonal antibody.
Learn More

OUR PARTNERS

OUR PARTNERS